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#Magnesium

Magnesium glycinate vs citrate vs threonate — which form for sleep, cramps, anxiety. EFSA safe upper intake and drug interactions.

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Magnesium is the fourth most abundant mineral in the body and a cofactor in 300+ enzymatic reactions. Up to half of adults in Central Europe get less than the recommended daily amount from food alone.

Forms. Choose the form by purpose. Glycinate and L-threonate are calming, well-tolerated and the most-cited forms for sleep and anxiety. Citrate is well-absorbed but tends to be laxative — useful when constipation coexists. Oxide has poor absorption (4%); skip it. Malate is studied for chronic fatigue and fibromyalgia.

Doses. RDAs range 310-420 mg/day for adults depending on sex and age. The EFSA Tolerable Upper Intake from supplements (separate from food) is 250 mg/day for adults — well-tolerated short-term doses up to 350-400 mg are common in trials.

Safety. Doses above 350 mg/day from supplements raise the risk of diarrhoea and, at very high amounts, magnesium toxicity (especially with reduced kidney function). Magnesium can reduce absorption of certain antibiotics (tetracyclines, quinolones), bisphosphonates and levothyroxine — separate dosing by 2-4 hours.

On HealthyHerbology we cover magnesium across sleep supplementation, women's menopause and PMS support, men's recovery and sleep, and paediatric ADHD-supportive nutrition (with cautions).

Frequently asked about Magnesium

Which form of magnesium is best for sleep?
Magnesium glycinate and magnesium L-threonate are the forms most often associated with sleep and relaxation. Magnesium citrate is well-absorbed but tends to be laxative.
Can I take magnesium every day?
The EFSA Tolerable Upper Intake from supplements (separate from food) is 250 mg/day for adults. Doses above this raise the risk of GI side effects and, at very high amounts, magnesium toxicity.
Does magnesium interact with medications?
Magnesium can reduce absorption of certain antibiotics (tetracyclines, quinolones), bisphosphonates and levothyroxine. Separate dosing by 2-4 hours and discuss with a pharmacist.
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